Program

164
16
7
5
3
3
2

Journal Year Published

7
23
16
20
13
26
17
13
8
16
8
10
4
2

Author

185
178
145
136
125
123
118
117
108
99
88
81
77
58
54
50
46
46
42
37

Category

79
74
72
29
15
12
6
1
1

Keyword

88
41
35
30
29
24
23
20
15
14
14
13
13
13
10
10
9
9
8
8

Journal

24
18
11
6
5
5
5
4
4
4
4
3
3
3
3
3
3
3
2
2

NCATS Publications

Prediction of human population responses to toxic compounds by a collaborative competition.


Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration , Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J


Nat. Biotechnol. , (33), 933-40, 2015.

Article Pubmed

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Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).


Yang SM, Yasgar A, Miller B, Lal-Nag M, Brimacombe K, Hu X, Sun H, Wang A, Xu X, Nguyen K, Oppermann U, Ferrer-Alegre M, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (58), 5967-78, 2015.

Article Pubmed

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Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.


Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, Cox K, Austin C, Simeonov A, Sittampalam S, Husain S, Franklin N, Wild DJ, Yang JJ, Sutherland JJ, Thomas C


PLoS ONE , (10), e0130796, 2015.

Article Pubmed

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.


Schreiber SL, et al.


Cell , (161), 1252-65, 2015.

Article Pubmed

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High-throughput screening for modulators of cellular contractile force.


Park CY, Zhou EH, Tambe D, Chen B, Lavoie T, Dowell M, Simeonov A, Maloney DJ, Marinkovic A, Tschumperlin DJ, Burger S, Frykenberg M, Butler JP, Stamer WD, Johnson M, Solway J, Fredberg JJ, Krishnan R


Integr Biol (Camb) , (7), 1318-24, 2015.

Article Pubmed

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Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.


Poletto M, Malfatti MC, Dorjsuren D, Scognamiglio PL, Marasco D, Vascotto C, Jadhav A, Maloney DJ, Wilson DM, Simeonov A, Tell G


Mol. Carcinog. , (55), 688-704, 2016.

Article Pubmed

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Induced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous System.


Hunsberger JG, Efthymiou AG, Malik N, Behl M, Mead IL, Zeng X, Simeonov A, Rao M


Stem Cells Dev. , (24), 1852-64, 2015.

Article Pubmed

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Discovery of a novel general anesthetic chemotype using high-throughput screening.


McKinstry-Wu AR, Bu W, Rai Bantukallu G, Lea WA, Weiser BP, Liang DF, Simeonov A, Jadhav A, Maloney DJ, Eckenhoff RG


Anesthesiology , (122), 325-33, 2015.

Article Pubmed

Gene expression analysis identifies global gene dosage sensitivity in cancer.


Fehrmann RS, Karjalainen JM, Krajewska M, Westra HJ, Maloney D, Simeonov A, Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, van Haagen HH, de Vries EG, te Meerman GJ, Wijmenga C, van Vugt MA, Franke L


Nat. Genet. , (47), 115-25, 2015.

Article Pubmed

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Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.


Taylor-Fishwick DA, Weaver J, Glenn L, Kuhn N, Rai Bantukallu G, Jadhav A, Simeonov A, Dudda A, Schmoll D, Holman TR, Maloney DJ, Nadler JL


Diabetologia , (58), 549-57, 2015.

Article Pubmed

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