Program

99
92
5
3
2
1
1

Journal Year Published

11
16
11
20
10
8
9
10
12
12
10
12
4

Author

145
185
178
136
125
123
118
117
108
99
88
81
77
58
54
50
46
46
42
37

Category

75
47
31
25
6
5
2
2
2
1
1

Keyword

58
43
32
19
18
16
15
15
14
13
13
12
12
12
11
11
10
10
10
9

Journal

16
13
12
5
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2

NCATS Publications

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.


Mott BT, Eastman R, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer-Alegre M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas C


Sci Rep , (5), 13891, 2015.

Article Pubmed

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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.


Zhang M, Mathews Griner LA, Ju W, Duveau D, Guha R, Petrus MN, Wen B, Maeda M, Shinn P, Ferrer-Alegre M, Conlon KD, Bamford RN, O'Shea JJ, Thomas C, Waldmann TA


Proc. Natl. Acad. Sci. U.S.A. , (112), 12480-5, 2015.

Article Pubmed

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.


Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, Cox K, Austin C, Simeonov A, Sittampalam S, Husain S, Franklin N, Wild DJ, Yang JJ, Sutherland JJ, Thomas C


PLoS ONE , (10), e0130796, 2015.

Article Pubmed

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A small molecule that inhibits OGT activity in cells.


Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau D, Tan ZW, Thomas C, Walker S


ACS Chem. Biol. , (10), 1392-7, 2015.

Article Pubmed

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Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway.


Yin Y, Li X, Sha X, Xi H, Li YF, Shao Y, Mai J, Virtue A, Lopez-Pastrana J, Meng S, Tilley DG, Monroy MA, Choi ET, Thomas C, Jiang X, Wang H, Yang XF


Arterioscler. Thromb. Vasc. Biol. , (35), 804-16, 2015.

Article Pubmed

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ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.


Wang S, Chen XA, Hu J, Jiang J, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, Wang Y


Mol. Cancer Ther. , (14), 877-88, 2015.

Article Pubmed

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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.


Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang J, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Vanden Heiden M, Xavier RJ, O'Neill LA


Cell Metab. , (21), 65-80, 2015.

Article Pubmed

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Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.


Lu G, Lomonosova E, Cheng X, Moran EA, Meyers MJ, Le Grice SF, Thomas C, Jiang J, Meck C, Hirsch DR, D'Erasmo MP, Suyabatmaz DM, Murelli RP, Tavis JE


Antimicrob. Agents Chemother. , (59), 1070-9, 2015.

Article Pubmed

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RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction.


Li J, Vootukuri S, Shang Y, Negri A, Jiang J, Nedelman M, Diacovo TG, Filizola M, Thomas C, Coller BS


Arterioscler. Thromb. Vasc. Biol. , (34), 2321-9, 2014.

Article Pubmed

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Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.


Ceribelli M, Kelly PN, Shaffer AL, Wright GW, Xiao W, Yang Y, Mathews Griner LA, Guha R, Shinn P, Keller JM, Liu D, Patel PR, Ferrer-Alegre M, Joshi S, Nerle S, Sandy P, Normant E, Thomas C, Staudt LM


Proc. Natl. Acad. Sci. U.S.A. , (111), 11365-70, 2014.

Article Pubmed

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