Program

99
92
5
3
2
1
1

Journal Year Published

3
12
16
11
20
10
8
9
10
12
12
10
12
4

Author

149
202
181
140
133
133
125
123
108
105
95
82
78
64
63
55
50
46
43
43

Category

75
47
31
25
6
5
2
2
2
1
1

Keyword

58
43
32
19
18
16
15
15
14
13
13
12
12
12
11
11
10
10
10
9

Journal

16
13
12
5
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2

NCATS Publications

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.


Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas C, Gai WP, Ringe D, Petsko GA, Hoang QQ


Proc. Natl. Acad. Sci. U.S.A. , (113), 9587-92, 2016.

Article Pubmed

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Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.


Kasbekar M, Fischer G, Mott BT, Yasgar A, Hyvönen M, Boshoff HI, Abell C, Barry CE, Thomas C


Proc. Natl. Acad. Sci. U.S.A. , (113), 7503-8, 2016.

Article Pubmed

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FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma.


Li Y, Bouchlaka MN, Wolff J, Grindle KM, Lu L, Qian S, Zhong X, Pflum N, Jobin P, Kahl BS, Eickhoff JC, Wuerzberger-Davis SM, Miyamoto S, Thomas C, Yang DT, Capitini CM, Rui L


Oncogene , 2016.

Article Pubmed

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NMDAR inhibition-independent antidepressant actions of ketamine metabolites.


Zanos P, Moaddel R, Morris P, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, Albuquerque EX, Thompson SM, Thomas C, Zarate CA, Gould TD


Nature , (533), 481-6, 2016.

Article Pubmed

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Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model.


Papaleo F, Yang F, Paterson C, Palumbo S, Carr GV, Wang Y, Floyd K, Huang W, Thomas C, Chen J, Weinberger DR, Law AJ


J. Neurosci. , (36), 4859-75, 2016.

Article Pubmed

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Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens.


Guha R, Mathews Griner LA, Keller JM, Zhang X, Fitzgerald D, Antignani A, Pastan I, Thomas C, Ferrer-Alegre M


J Biomol Screen , 2016.

Article Pubmed

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RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.


Baranello L, Wojtowicz D, Cui K, Devaiah BN, Chung HJ, Chan-Salis KY, Guha R, Wilson K, Zhang X, Zhang H, Piotrowski J, Thomas C, Singer DS, Pugh BF, Pommier Y, Przytycka TM, Kouzine F, Lewis BA, Zhao K, Levens D


Cell , (165), 357-71, 2016.

Article Pubmed

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Structure Property Relationships of Carboxylic Acid Isosteres.


Lassalas P, Gay B, Lasfargeas C, James MJ, Tran V, Vijayendran KG, Brunden KR, Kozlowski MC, Thomas C, Smith AB, Huryn DM, Ballatore C


J. Med. Chem. , (59), 3183-203, 2016.

Article Pubmed

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Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.


Smith SJ, Pauly GT, Akram A, Melody K, Rai Bantukallu G, Maloney DJ, Ambrose Z, Thomas C, Schneider JT, Hughes SH


Retrovirology , (13), 11, 2016.

Article Pubmed

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