Program

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Journal Year Published

5
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5

Author

62
201
181
149
139
133
133
125
123
108
105
95
82
78
63
54
50
46
43
43

Category

22
18
15
14
7
5
3
1
1

Keyword

32
15
15
13
11
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Journal

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NCATS Publications

Chiral kinase inhibitors.


Jiang J, Shen M, Thomas C, Boxer MB


Curr Top Med Chem , (11), 800-9, 2011.

Pubmed

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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Jiang J, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin C, Park HW, Inglese J, Cantley LC, Auld DS, Thomas C


Bioorg. Med. Chem. Lett. , (20), 3387-93, 2010.

Article Pubmed

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A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety.


Boxer MB, Quinn AM, Shen M, Jadhav A, Leister W, Simeonov A, Auld DS, Thomas C


ChemMedChem , (5), 730-8, 2010.

Article Pubmed

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Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.


Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai Bantukallu G, Battaile KP, Thomas C, Simeonov A, Hanzlik RP, Inglese J


Proc. Natl. Acad. Sci. U.S.A. , (107), 4878-83, 2010.

Article Pubmed

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Boxer MB, Jiang J, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin C, Park HW, Inglese J, Cantley LC, Auld DS, Thomas C


J. Med. Chem. , (53), 1048-55, 2010.

Article Pubmed

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Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.


Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin C, Thomas C, Shoichet BK, Maloney DJ


J. Med. Chem. , (53), 52-60, 2010.

Article Pubmed

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Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.


Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin C, Lloyd DG, Auld DS


Nat. Biotechnol. , (27), 1050-5, 2009.

Article Pubmed

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