Program

56
11
4
2
1
1
1
1

Journal Year Published

7
1
6
1
7
5
6
8
7
6
5
5

Author

64
202
181
149
140
133
133
125
123
108
105
95
82
78
63
55
50
46
43
43

Category

22
18
15
14
7
5
3
1
1

Keyword

32
15
15
13
11
10
10
9
8
8
7
7
7
6
6
6
6
6
5
5

Journal

9
6
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1

NCATS Publications

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Walsh MJ, Brimacombe K, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas C, Boxer MB


Bioorg. Med. Chem. Lett. , (21), 6322-7, 2011.

Article Pubmed

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Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.


Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ


PLoS ONE , (6), e23679, 2011.

Article Pubmed

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Chiral kinase inhibitors.


Jiang J, Shen M, Thomas C, Boxer MB


Curr Top Med Chem , (11), 800-9, 2011.

Pubmed

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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Jiang J, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin C, Park HW, Inglese J, Cantley LC, Auld DS, Thomas C


Bioorg. Med. Chem. Lett. , (20), 3387-93, 2010.

Article Pubmed

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A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety.


Boxer MB, Quinn AM, Shen M, Jadhav A, Leister W, Simeonov A, Auld DS, Thomas C


ChemMedChem , (5), 730-8, 2010.

Article Pubmed

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Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.


Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai Bantukallu G, Battaile KP, Thomas C, Simeonov A, Hanzlik RP, Inglese J


Proc. Natl. Acad. Sci. U.S.A. , (107), 4878-83, 2010.

Article Pubmed

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Boxer MB, Jiang J, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin C, Park HW, Inglese J, Cantley LC, Auld DS, Thomas C


J. Med. Chem. , (53), 1048-55, 2010.

Article Pubmed

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Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.


Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin C, Thomas C, Shoichet BK, Maloney DJ


J. Med. Chem. , (53), 52-60, 2010.

Article Pubmed

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