Program

125
5
3
1
1

Journal Year Published

1
15
11
11
8
18
12
8
5
11
8
13
2
2

Author

125
182
174
134
134
118
116
114
108
88
86
81
73
56
51
50
43
43
42
34

Category

58
49
44
23
14
4
4
1
1
1

Keyword

63
33
27
26
22
21
21
20
14
13
12
10
10
10
9
8
8
8
7
7

Journal

23
15
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1

NCATS Publications

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.


Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci D, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M


Blood , (124), 2271-9, 2014.

Article Pubmed

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A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein.


Carver J, Dexheimer TS, Hsu D, Weng MT, Smith JL, Guha R, Jadhav A, Simeonov A, Luo J


PLoS ONE , (9), e103836, 2014.

Article Pubmed

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Biochemical assays for the discovery of TDP1 inhibitors.


Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai Bantukallu G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y


Mol. Cancer Ther. , (13), 2116-26, 2014.

Article Pubmed

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Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.


Abdel-Fatah TM, Russell R, Albarakati N, Maloney DJ, Dorjsuren D, Rueda OM, Moseley P, Mohan V, Sun H, Abbotts R, Mukherjee A, Agarwal D, Illuzzi JL, Jadhav A, Simeonov A, Ball G, Chan S, Caldas C, Ellis IO, Wilson DM, Madhusudan S


Mol Oncol , (8), 1326-38, 2014.

Article Pubmed

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Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.


Abbotts R, Jewell R, Nsengimana J, Maloney DJ, Simeonov A, Seedhouse C, Elliott F, Laye J, Walker C, Jadhav A, Grabowska A, Ball G, Patel PM, Newton-Bishop J, Wilson DM, Madhusudan S


Oncotarget , (5), 3273-86, 2014.

Article Pubmed

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Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.


Murai J, Marchand C, Shahane SA, Sun H, Huang R, Zhang Y, Chergui A, Ji J, Doroshow JH, Jadhav A, Takeda S, Xia M, Pommier Y


DNA Repair (Amst.) , (21), 177-82, 2014.

Article Pubmed

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Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.


Rai Bantukallu G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, Holman TR


J. Med. Chem. , (57), 4035-48, 2014.

Article Pubmed

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A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.


Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci D, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z


Nat. Chem. Biol. , (10), 298-304, 2014.

Article Pubmed

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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.


Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau D, Jiang J, Michael S, Mierzwa T, Huang W, Walsh MJ, Mott BT, Patel P, Leister W, Maloney DJ, LeClair C, Rai Bantukallu G, Jadhav A, Peyser BD, Austin C, Martin SE, Simeonov A, Ferrer-Alegre M, Staudt LM, Thomas C


Proc. Natl. Acad. Sci. U.S.A. , (111), 2349-54, 2014.

Article Pubmed

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