Program

56
11
4
2
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1
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1

Journal Year Published

1
6
1
7
5
6
8
7
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5

Author

57
183
175
135
134
127
119
118
115
108
90
87
81
74
52
50
44
43
42
34

Category

22
18
15
14
7
5
3
1
1

Keyword

32
15
15
13
11
10
10
9
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7
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Journal

9
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NCATS Publications

Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.


Cruz PG, Auld DS, Schultz PJ, Lovell S, Battaile KP, MacArthur R, Shen M, Tamayo-Castillo G, Inglese J, Sherman DH


Chem. Biol. , (18), 1442-52, 2011.

Article Pubmed

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.


Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang J, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas C, Vander Heiden MG, Cantley LC


Science , (334), 1278-83, 2011.

Article Pubmed

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2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Walsh MJ, Brimacombe K, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas C, Boxer MB


Bioorg. Med. Chem. Lett. , (21), 6322-7, 2011.

Article Pubmed

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Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.


Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ


PLoS ONE , (6), e23679, 2011.

Article Pubmed

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Chiral kinase inhibitors.


Jiang J, Shen M, Thomas C, Boxer MB


Curr Top Med Chem , (11), 800-9, 2011.

Pubmed

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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Jiang J, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin C, Park HW, Inglese J, Cantley LC, Auld DS, Thomas C


Bioorg. Med. Chem. Lett. , (20), 3387-93, 2010.

Article Pubmed

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Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.


Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai Bantukallu G, Battaile KP, Thomas C, Simeonov A, Hanzlik RP, Inglese J


Proc. Natl. Acad. Sci. U.S.A. , (107), 4878-83, 2010.

Article Pubmed

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