Program

56
11
4
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Journal Year Published

5
1
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7
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5

Author

62
201
181
149
139
133
133
125
123
108
105
95
82
78
63
54
50
46
43
43

Category

22
18
15
14
7
5
3
1
1

Keyword

32
15
15
13
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10
10
9
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Journal

9
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1

NCATS Publications

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.


Anastasiou D, et al.


Nat. Chem. Biol. , (8), 839-47, 2012.

Article Pubmed

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A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.


Morgan HP, Walsh MJ, Blackburn EA, Wear MA, Boxer MB, Shen M, Veith H, McNae IW, Nowicki MW, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD


Biochem. J. , (448), 67-72, 2012.

Article Pubmed

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Application of a homogenous membrane potential assay to assess mitochondrial function.


Sakamuru S, Li X, Attene-Ramos MS, Huang R, Lu J, Shou L, Shen M, Tice RR, Austin C, Xia M


Physiol. Genomics , (44), 495-503, 2012.

Article Pubmed

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Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.


Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas C, Filizola M, Springer TA, Coller BS


Sci Transl Med , (4), 125ra32, 2012.

Article Pubmed

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Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.


Cruz PG, Auld DS, Schultz PJ, Lovell S, Battaile KP, MacArthur R, Shen M, Tamayo-Castillo G, Inglese J, Sherman DH


Chem. Biol. , (18), 1442-52, 2011.

Article Pubmed

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.


Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang J, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas C, Vander Heiden MG, Cantley LC


Science , (334), 1278-83, 2011.

Article Pubmed

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2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Walsh MJ, Brimacombe K, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas C, Boxer MB


Bioorg. Med. Chem. Lett. , (21), 6322-7, 2011.

Article Pubmed

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Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.


Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ


PLoS ONE , (6), e23679, 2011.

Article Pubmed

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