Program

125
5
3
1
1

Journal Year Published

1
15
11
11
8
18
12
8
5
11
8
13
2
2

Author

125
182
174
134
134
118
116
114
108
88
86
81
73
56
51
50
43
43
42
34

Category

58
49
44
23
14
4
4
1
1
1

Keyword

63
33
27
26
22
21
21
20
14
13
12
10
10
10
9
8
8
8
7
7

Journal

23
15
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1

NCATS Publications

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.


Schreiber SL, et al.


Cell , (161), 1252-65, 2015.

Article Pubmed

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.


Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe K, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ


Nature , (522), 216-20, 2015.

Article Pubmed

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Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.


Poletto M, Malfatti MC, Dorjsuren D, Scognamiglio PL, Marasco D, Vascotto C, Jadhav A, Maloney DJ, Wilson DM, Simeonov A, Tell G


Mol. Carcinog. , (55), 688-704, 2016.

Article Pubmed

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Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.


Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, Zhang Y, Curtis M, Schryver EM, Bettis S, Jadhav A, Boxer MB, Li Z, Ferrer-Alegre M, Lengyel E


Nat Commun , (6), 6220, 2015.

Article Pubmed

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Discovery of a novel general anesthetic chemotype using high-throughput screening.


McKinstry-Wu AR, Bu W, Rai Bantukallu G, Lea WA, Weiser BP, Liang DF, Simeonov A, Jadhav A, Maloney DJ, Eckenhoff RG


Anesthesiology , (122), 325-33, 2015.

Article Pubmed

Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.


Taylor-Fishwick DA, Weaver J, Glenn L, Kuhn N, Rai Bantukallu G, Jadhav A, Simeonov A, Dudda A, Schmoll D, Holman TR, Maloney DJ, Nadler JL


Diabetologia , (58), 549-57, 2015.

Article Pubmed

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Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.


Gormally MV, Dexheimer TS, Marsico G, Sanders DA, Lowe C, Matak-Vinković D, Michael S, Jadhav A, Rai Bantukallu G, Maloney DJ, Simeonov A, Balasubramanian S


Nat Commun , (5), 5165, 2014.

Article Pubmed

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Covalent small molecule inhibitors of Ca(2+)-bound S100B.


Cavalier MC, Pierce AD, Wilder PT, Alasady MJ, Hartman KG, Neau DB, Foley TL, Jadhav A, Maloney DJ, Simeonov A, Toth EA, Weber DJ


Biochemistry , (53), 6628-40, 2014.

Article Pubmed

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A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2.


Jameson JB, Kantz A, Schultz L, Kalyanaraman C, Jacobson MP, Maloney DJ, Jadhav A, Simeonov A, Holman TR


PLoS ONE , (9), e104094, 2014.

Article Pubmed

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