Program

585
107
103
99
36
3
769
26
22
16
11
10
10
9
4

Journal Year Published

21
94
73
129
80
82
75
65
51
40
40
29
14
4
3
2

Author

183
155
134
133
127
118
118
114
108
90
86
81
69
57
52
50
43
42
42
34

Category

340
309
283
84
69
49
21
19
12
9
3
2

Keyword

367
210
114
110
88
79
74
70
66
59
54
53
46
45
40
40
37
35
35
34

Journal

47
37
28
28
25
24
20
16
14
14
13
12
12
11
10
10
9
9
9
8

NCATS Publications

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.


Manthei KA, Yang SM, Baljinnyam B, Chang L, Glukhova A, Yuan W, Freeman LA, Maloney DJ, Schwendeman A, Remaley AT, Jadhav A, Tesmer JJ


Elife , (7), 2018.

Article Pubmed

Sample image from publication page

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.


Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales S, Lal-Nag M, Rai Bantukallu G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K


Cancer Cell , (34), 939-953.e9, 2018.

Article Pubmed

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High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.


Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Fang L, Hynes PG, Alilin AN, Lake R, Abbey YC, Cawley J, Tice CM, Yin J, McKnight C, Klumpp-Thomas C, Zhang X, Guha R, Hoover S, Simpson RM, Nguyen HM, Corey E, Thomas C, Proia DA, Kelly K


Sci Rep , (8), 17239, 2018.

Article Pubmed

Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4.


Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Yang SM, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK


Mol. Cancer Ther. , 2018.

Article Pubmed

A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma.


Guenther LM, Dharia NV, Ross L, Conway A, Robichaud AL, Catlett JL, Wechsler CS, Frank ES, Goodale A, Church AJ, Tseng YY, Guha R, McKnight C, Janeway KA, Boehm JS, Mora J, Davis MI, Alexe G, Piccioni F, Stegmaier K


Clin. Cancer Res. , 2018.

Article Pubmed

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.


Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

Sample image from publication page

DrugCentral 2018: an update.


Ursu O, Holmes J, Bologa CG, Yang JJ, Mathias SL, Stathias V, Nguyen T, Schürer S, Oprea T


Nucleic Acids Res. , (47), D963-D970, 2019.

Article Pubmed

Sample image from publication page

Glypican-3 Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.


Fu Y, Urban DJ, Nani RR, Zhang YF, Li N, Fu H, Shah H, Gorka AP, Guha R, Chen L, Hall M, Schnermann MJ, Ho M


Hepatology , 2018.

Article Pubmed