Program

56
11
4
2
1
1
1
1

Journal Year Published

13
1
6
1
7
5
6
8
7
6
5
5

Author

70
212
185
156
149
137
135
129
127
108
107
96
83
79
70
63
53
50
46
46

Category

22
18
15
14
7
5
3
1
1

Keyword

32
15
15
13
11
10
10
9
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8
7
7
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6
6
6
6
6
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5

Journal

9
6
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1

NCATS Publications

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.


Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe K, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ


Nature , (522), 216-20, 2015.

Article Pubmed

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Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.


Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, Zhang Y, Curtis M, Schryver EM, Bettis S, Jadhav A, Boxer MB, Li Z, Ferrer-Alegre M, Lengyel E


Nat Commun , (6), 6220, 2015.

Article Pubmed

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Structure activity relationships of human galactokinase inhibitors.


Liu L, Tang M, Walsh MJ, Brimacombe K, Pragani R, Tanega C, Rohde JM, Baker H, Fernandez E, Blackman B, Bougie JM, Leister WH, Auld DS, Shen M, Lai K, Boxer MB


Bioorg. Med. Chem. Lett. , (25), 721-7, 2015.

Article Pubmed

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Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.


Brimacombe K, Walsh MJ, Liu L, Vásquez-Valdivieso MG, Morgan HP, McNae I, Fothergill-Gilmore LA, Michels PA, Auld DS, Simeonov A, Walkinshaw MD, Shen M, Boxer MB


ACS Med Chem Lett , (5), 12-7, 2014.

Article Pubmed

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Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.


Blackford JA, Brimacombe K, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin C, Simons SS


Mol. Endocrinol. , (28), 1194-206, 2014.

Article Pubmed

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Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.


Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, Popovici-Muller J, DeLaBarre B, Artin E, Thorne N, Auld DS, Li Z, Dang L, Boxer MB, Simeonov A


J. Biol. Chem. , (289), 13717-25, 2014.

Article Pubmed

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Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia.


Fiskus W, Saba N, Shen M, Ghias M, Liu J, Gupta SD, Chauhan L, Rao R, Gunewardena S, Schorno K, Austin C, Maddocks K, Byrd J, Melnick A, Huang P, Wiestner A, Bhalla KN


Cancer Res. , (74), 2520-32, 2014.

Article Pubmed

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A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.


Jiang J, McCoy JG, Shen M, LeClair C, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G, Choi WS, Volpi E, Fernandez J, Babayeva M, Nedelman MA, Filizola M, Coller BS, Thomas C


Bioorg. Med. Chem. Lett. , (24), 1148-53, 2014.

Article Pubmed

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