Program

580
106
103
99
36
3
769
26
22
16
11
10
10
9
4

Journal Year Published

17
94
73
129
80
81
75
65
51
40
40
29
14
4
3
2

Author

182
154
133
133
125
118
115
113
108
88
85
81
68
56
51
50
42
42
42
34

Category

338
309
283
83
68
49
21
19
12
9
3
2

Keyword

367
209
114
109
88
79
74
70
66
59
54
53
46
45
40
40
37
35
35
34

Journal

47
37
28
28
24
24
20
16
14
14
13
12
12
11
10
10
9
9
9
8

NCATS Publications

Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.


Iniguez AB, Alexe G, Wang EJ, Roti G, Patel S, Chen L, Kitara S, Conway A, Robichaud AL, Stolte B, Bandopadhayay P, Goodale A, Pantel S, Lee Y, Cheff D, Hall M, Guha R, Davis MI, Menard M, Nasholm N, Weiss WA, Qi J, Beroukhim R, Piccioni F, Johannessen C, Stegmaier K


Cancer Cell , (34), 922-938.e7, 2018.

Article Pubmed

Sample image from publication page

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.


Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer-Alegre M, Slusher BS


Sci Rep , (8), 17715, 2018.

Article Pubmed

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KDM5B Promotes Drug Resistance by Regulating Melanoma Propagating Cell Subpopulations.


Liu X, Zhang SM, McGeary MK, Krykbaeva I, Lai L, Jansen DJ, Kales S, Simeonov A, Hall M, Kelly DP, Bosenberg MW, Yan Q


Mol. Cancer Ther. , 2018.

Article Pubmed

AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.


Hakim C, Wasala NB, Nelson CE, Wasala LP, Yue Y, Louderman JA, Lessa TB, Dai A, Zhang K, Jenkins GJ, Nance ME, Pan X, Kodippili K, Yang N, Chen SJ, Gersbach CA, Duan D


JCI Insight , (3), 2018.

Article Pubmed

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R)-hydroxynorketamine.


Highland JN, Morris P, Zanos P, Lovett J, Ghosh S, Wang A, Zarate CA, Thomas C, Moaddel R, Gould TD


J. Psychopharmacol. (Oxford) , 269881118812095, 2018.

Article Pubmed

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.


Manthei KA, Yang SM, Baljinnyam B, Chang L, Glukhova A, Yuan W, Freeman LA, Maloney DJ, Schwendeman A, Remaley AT, Jadhav A, Tesmer JJ


Elife , (7), 2018.

Article Pubmed

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.


Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales S, Lal-Nag M, Rai Bantukallu G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K


Cancer Cell , (34), 939-953.e9, 2018.

Article Pubmed

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High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.


Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Fang L, Hynes PG, Alilin AN, Lake R, Abbey YC, Cawley J, Tice CM, Yin J, McKnight C, Klumpp-Thomas C, Zhang X, Guha R, Hoover S, Simpson RM, Nguyen HM, Corey E, Thomas C, Proia DA, Kelly K


Sci Rep , (8), 17239, 2018.

Article Pubmed

Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4.


Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Yang SM, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK


Mol. Cancer Ther. , 2018.

Article Pubmed