Program

42
5
1
1
1

Journal Year Published

4
7
2
5
3
7
4
6
1
3
3
1

Author

46
212
185
156
149
137
135
129
127
108
107
96
83
79
70
70
63
53
50
46

Category

26
12
11
10
2
1
1

Keyword

22
14
9
8
7
6
6
5
5
4
4
4
3
3
3
3
3
3
3
3

Journal

12
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

NCATS Publications

Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.


Taylor-Fishwick DA, Weaver J, Glenn L, Kuhn N, Rai Bantukallu G, Jadhav A, Simeonov A, Dudda A, Schmoll D, Holman TR, Maloney DJ, Nadler JL


Diabetologia , (58), 549-57, 2015.

Article Pubmed

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Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.


Gormally MV, Dexheimer TS, Marsico G, Sanders DA, Lowe C, Matak-Vinković D, Michael S, Jadhav A, Rai Bantukallu G, Maloney DJ, Simeonov A, Balasubramanian S


Nat Commun , (5), 5165, 2014.

Article Pubmed

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Biochemical assays for the discovery of TDP1 inhibitors.


Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai Bantukallu G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y


Mol. Cancer Ther. , (13), 2116-26, 2014.

Article Pubmed

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Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.


Rai Bantukallu G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, Holman TR


J. Med. Chem. , (57), 4035-48, 2014.

Article Pubmed

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A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.


Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai Bantukallu G, Lejeune C, Choi H, Yeh TL, Chan MC, Mott BT, McCullagh JS, Maloney DJ, Schofield CJ, Kawamura A


ChemMedChem , (9), 566-71, 2014.

Article Pubmed

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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.


Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau D, Jiang J, Michael S, Mierzwa T, Huang W, Walsh MJ, Mott BT, Patel P, Leister W, Maloney DJ, LeClair C, Rai Bantukallu G, Jadhav A, Peyser BD, Austin C, Martin SE, Simeonov A, Ferrer-Alegre M, Staudt LM, Thomas C


Proc. Natl. Acad. Sci. U.S.A. , (111), 2349-54, 2014.

Article Pubmed

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In vitro screening of compounds against laboratory and field isolates of human hookworm reveals quantitative differences in anthelmintic susceptibility.


Treger RS, Otchere J, Keil MF, Quagraine JE, Rai Bantukallu G, Mott BT, Humphries DL, Wilson M, Cappello M, Vermeire JJ


Am. J. Trop. Med. Hyg. , (90), 71-4, 2014.

Article Pubmed

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.


Hoobler EK, Rai Bantukallu G, Warrilow AG, Perry SC, Smyrniotis CJ, Jadhav A, Simeonov A, Parker JE, Kelly DE, Maloney DJ, Kelly SL, Holman TR


PLoS ONE , (8), e65928, 2013.

Article Pubmed

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12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.


Yeung J, Apopa PL, Vesci J, Stolla M, Rai Bantukallu G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M


Thromb. Haemost. , (110), 569-81, 2013.

Article Pubmed

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