Program

51
3
3
2
1

Journal Year Published

15
6
10
7
9
5
7
8
1
2

Author

70
212
185
156
149
137
135
129
127
108
107
96
83
79
70
63
53
50
46
46

Category

35
14
10
8
5
1

Keyword

23
11
11
11
9
7
7
6
5
5
5
5
5
4
4
4
4
4
3
3

Journal

11
6
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1

NCATS Publications

A large scale high throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha.


Sengupta N, Jović M, Barnaeva E, Kim D, Hu X, Southall N, Dejmek M, Mejdrova I, Nencka R, Baumlova A, Chalupska D, Boura E, Ferrer-Alegre M, Marugan J, Balla T


J. Lipid Res. , 2019.

Article Pubmed

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DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.


Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer-Alegre M, Slusher BS


Sci Rep , (8), 17715, 2018.

Article Pubmed

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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.


Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

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Discovery and lead identification of quinazoline-based BRD4 inhibitors.


Yang SM, Urban DJ, Yoshioka M, Strovel JW, Fletcher S, Wang A, Xu X, Shah P, Hu X, Hall M, Jadhav A, Maloney DJ


Bioorg. Med. Chem. Lett. , (28), 3483-3488, 2018.

Article Pubmed

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KDM5 histone demethylases repress immune response via suppression of STING.


Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai Bantukallu G, Kales S, Henderson M, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall M, Cheng X, Shadel GS, Yan Q


PLoS Biol. , (16), e2006134, 2018.

Article Pubmed

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Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.


Yang S, et al.


Cell Discov , (4), 31, 2018.

Article Pubmed

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Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.


Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

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