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Journal

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NCATS Publications

Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer.


Chen I, Mathews-Greiner L, Li D, Abisoye-Ogunniyan A, Ray S, Bian Y, Shukla V, Zhang X, Guha R, Thomas C, Gryder B, Zacharia A, Beane JD, Ravichandran S, Ferrer-Alegre M, Rudloff U


J Transl Med , (15), 92, 2017.

Article Pubmed

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PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability.


Gryder BE, Yohe ME, Chou HC, Zhang X, Marques J, Wachtel M, Schaefer B, Sen N, Song YK, Gualtieri A, Pomella S, Rota R, Cleveland A, Wen X, Sindiri S, Wei JS, Barr FG, Das S, Andresson T, Guha R, Lal-Nag M, Ferrer-Alegre M, Shern JF, Zhao K, Thomas C, Khan J


Cancer Discov , 2017.

Article Pubmed

Large-scale pharmacological profiling of 3D tumor models of cancer cells.


Mathews Griner LA, Zhang X, Guha R, McKnight C, Goldlust IS, Lal-Nag M, Wilson K, Michael S, Titus S, Shinn P, Thomas C, Ferrer-Alegre M


Cell Death Dis , (7), e2492, 2016.

Article Pubmed

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A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm.


Ceribelli M, Hou ZE, Kelly PN, Huang DW, Wright G, Ganapathi K, Evbuomwan MO, Pittaluga S, Shaffer AL, Marcucci G, Forman SJ, Xiao W, Guha R, Zhang X, Ferrer-Alegre M, Chaperot L, Plumas J, Jaffe ES, Thomas C, Reizis B, Staudt LM


Cancer Cell , (30), 764-778, 2016.

Article Pubmed

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Cancer network activity associated with therapeutic response and synergism.


Serra-Musach J, Mateo F, Capdevila-Busquets E, de Garibay GR, Zhang X, Guha R, Thomas C, Grueso J, Villanueva A, Jaeger S, Heyn H, Vizoso M, Pérez H, Cordero A, Gonzalez-Suarez E, Esteller M, Moreno-Bueno G, Tjärnberg A, Lázaro C, Serra V, Arribas J, Benson M, Gustafsson M, Ferrer-Alegre M, Aloy P, Pujana MÀ


Genome Med , (8), 88, 2016.

Article Pubmed

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Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens.


Guha R, Mathews Griner LA, Keller JM, Zhang X, Fitzgerald D, Antignani A, Pastan I, Thomas C, Ferrer-Alegre M


J Biomol Screen , 2016.

Article Pubmed

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RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.


Baranello L, Wojtowicz D, Cui K, Devaiah BN, Chung HJ, Chan-Salis KY, Guha R, Wilson K, Zhang X, Zhang H, Piotrowski J, Thomas C, Singer DS, Pugh BF, Pommier Y, Przytycka TM, Kouzine F, Lewis BA, Zhao K, Levens D


Cell , (165), 357-71, 2016.

Article Pubmed

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Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin's lymphoma.


Ju W, Zhang M, Wilson K, Petrus MN, Bamford RN, Zhang X, Guha R, Ferrer-Alegre M, Thomas C, Waldmann TA


Proc. Natl. Acad. Sci. U.S.A. , (113), 1624-9, 2016.

Article Pubmed

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Genomic Analysis of Invasive Human Bone Marrow Derived Mesenchymal Stem Cells.


Mathews LA, Hurt EM, Zhang X, Farrar WL


J Bone Marrow Res , (1), 122, 2013.

Article Pubmed

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