Program

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Journal Year Published

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Author

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Category

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Keyword

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Journal

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NCATS Publications

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages.


Aflaki E, Moaven N, Borger DK, Lopez G, Westbroek W, Chae JJ, Marugan J, Patnaik S, Maniwang E, Gonzalez AN, Sidransky E


Aging Cell , (15), 77-88, 2016.

Article Pubmed

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Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs.


Aflaki E, Stubblefield BK, Maniwang E, Lopez G, Moaven N, Goldin E, Marugan J, Patnaik S, Dutra A, Southall N, Zheng W, Tayebi N, Sidransky E


Sci Transl Med , (6), 240ra73, 2014.

Article Pubmed

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Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects.


Hoskins JW, Ofori LO, Chen C, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan J, Zheng W, Austin C, Disney MD, Miller BL, Thornton CA


Nucleic Acids Res. , (42), 6591-602, 2014.

Article Pubmed

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Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.


Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer-Alegre M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R


J. Biol. Chem. , (289), 16349-61, 2014.

Article Pubmed

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Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.


Patnaik S, Marugan J, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe K, Austin C


J. Med. Chem. , (56), 9045-56, 2013.

Article Pubmed

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Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.


Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen C, Hoskins J, Southall N, Marugan J, Patnaik S, Zheng W, Austin C, Schatz GC, Sobczak K, Thornton CA, Disney MD


Nat Commun , (4), 2044, 2013.

Article Pubmed

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A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.


Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin C, Eskay R, Ciccocioppo R, Zheng W, Heilig M


J. Neurosci. , (33), 10132-42, 2013.

Article Pubmed

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Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.


Patnaik S, Zheng W, Choi JH, Motabar O, Southall N, Westbroek W, Lea WA, Velayati A, Goldin E, Sidransky E, Leister W, Marugan J


J. Med. Chem. , (55), 5734-48, 2012.

Article Pubmed

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Non-iminosugar glucocerebrosidase small molecule chaperones.


Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E


Medchemcomm , (3), 56-60, 2012.

Article Pubmed

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Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.


Holm TM, Habashi JP, Doyle JJ, Bedja D, Chen Y, van Erp C, Lindsay ME, Kim D, Schoenhoff F, Cohn RD, Loeys BL, Thomas C, Patnaik S, Marugan J, Judge DP, Dietz HC


Science , (332), 358-61, 2011.

Article Pubmed

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