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Author

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Keyword

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Journal

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NCATS Publications

CD28 and ITK signals regulate autoreactive T cell trafficking.


Jain N, Miu B, Jiang J, McKinstry KK, Prince A, Swain SL, Greiner DL, Thomas C, Sanderson MJ, Berg LJ, Kang J


Nat. Med. , (19), 1632-7, 2013.

Article Pubmed

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Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.


McDonnell SR, Hwang SR, Rolland D, Murga-Zamalloa C, Basrur V, Conlon KP, Fermin D, Wolfe T, Raskind A, Ruan C, Jiang J, Thomas C, Hogaboam CM, Burant CF, Elenitoba-Johnson KS, Lim MS


Blood , (122), 958-68, 2013.

Article Pubmed

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.


Nayar R, Enos M, Prince A, Shin H, Hemmers S, Jiang J, Klein U, Thomas C, Berg LJ


Proc. Natl. Acad. Sci. U.S.A. , (109), E2794-802, 2012.

Article Pubmed

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.


Anastasiou D, et al.


Nat. Chem. Biol. , (8), 839-47, 2012.

Article Pubmed

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.


Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang J, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas C, Vander Heiden MG, Cantley LC


Science , (334), 1278-83, 2011.

Article Pubmed

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Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.


Chung S, Himmel DM, Jiang J, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas C, Arnold E, Le Grice SF


J. Med. Chem. , (54), 4462-73, 2011.

Article Pubmed

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Chiral kinase inhibitors.


Jiang J, Shen M, Thomas C, Boxer MB


Curr Top Med Chem , (11), 800-9, 2011.

Pubmed

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CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.


Ju W, Zhang M, Jiang J, Thomas C, Oh U, Bryant BR, Chen J, Sato N, Tagaya Y, Morris JC, Janik JE, Jacobson S, Waldmann TA


Blood , (117), 1938-46, 2011.

Article Pubmed

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Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.


Feng J, Petersen CD, Coy DH, Jiang J, Thomas C, Pollak MR, Wank SA


Proc. Natl. Acad. Sci. U.S.A. , (107), 17791-6, 2010.

Article Pubmed

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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.


Jiang J, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin C, Park HW, Inglese J, Cantley LC, Auld DS, Thomas C


Bioorg. Med. Chem. Lett. , (20), 3387-93, 2010.

Article Pubmed

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