Program

769
585
109
107
103
36
26
22
16
11
10
10
9
4
3
1

Journal Year Published

53
74
112
103
189
334
339
388
128
66
52
51
37
20
10
4
5
6
3
3

Author

201
181
149
139
133
133
125
123
108
105
95
82
78
63
62
54
50
46
43
43

Category

377
362
314
112
86
72
21
20
19
19
3
2

Keyword

1270
612
563
415
347
304
212
208
160
146
130
122
112
111
100
99
91
83
82
82

Journal

55
55
46
31
30
28
21
19
18
17
17
17
17
17
16
16
16
15
14
13

NCATS Publications

Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.


Stachel SJ, Steele TG, Petrocchi A, Haugabook S, McGaughey G, Katharine Holloway M, Allison T, Munshi S, Zuck P, Colussi D, Tugasheva K, Wolfe A, Graham SL, Vacca JP


Bioorg. Med. Chem. Lett. , (22), 240-4, 2012.

Article Pubmed

Titration-based screening for evaluation of natural product extracts: identification of an aspulvinone family of luciferase inhibitors.


Cruz PG, Auld DS, Schultz PJ, Lovell S, Battaile KP, MacArthur R, Shen M, Tamayo-Castillo G, Inglese J, Sherman DH


Chem. Biol. , (18), 1442-52, 2011.

Article Pubmed

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Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.


Chen J, Dexheimer TS, Ai Y, Liang Q, Villamil MA, Inglese J, Maloney DJ, Jadhav A, Simeonov A, Zhuang Z


Chem. Biol. , (18), 1390-400, 2011.

Article Pubmed

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Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A.


Cardellina JH, Vieira RC, Eccard V, Skerry J, Montgomery V, Campbell Y, Roxas-Duncan V, Leister W, LeClair C, Maloney DJ, Padula D, Pescitelli G, Khavrutskii I, Hu X, Wallqvist A, Smith LA


ACS Med Chem Lett , (2), 396-401, 2011.

Article Pubmed

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Natural history of MELAS associated with mitochondrial DNA m.3243A>G genotype.


Kaufmann P, Engelstad K, Wei Y, Kulikova R, Oskoui M, Sproule DM, Battista V, Koenigsberger DY, Pascual JM, Shanske S, Sano M, Mao X, Hirano M, Shungu DC, Dimauro S, De Vivo DC


Neurology , (77), 1965-71, 2011.

Article Pubmed

Common seed analysis to identify off-target effects in siRNA screens.


Marine S, Bahl A, Ferrer-Alegre M, Buehler E


J Biomol Screen , (17), 370-8, 2012.

Article Pubmed

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Classification of scaffold-hopping approaches.


Sun H, Tawa G, Wallqvist A


Drug Discov. Today , (17), 310-24, 2012.

Article Pubmed

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.


Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang J, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas C, Vander Heiden MG, Cantley LC


Science , (334), 1278-83, 2011.

Article Pubmed

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Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3.


Tang LY, Yamashita M, Coussens NP, Tang Y, Wang X, Li C, Deng CX, Cheng SY, Zhang YE


EMBO J. , (30), 4777-89, 2011.

Article Pubmed

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