Program

769
585
109
107
103
36
26
22
16
11
10
10
9
4
3
1

Journal Year Published

4
55
111
103
188
334
338
388
128
65
52
51
37
20
10
4
5
6
3
3

Author

185
178
145
136
125
123
118
117
108
99
88
81
77
58
54
50
46
46
42
37

Category

377
362
314
112
86
72
21
20
19
19
3
2

Keyword

1262
610
560
411
345
302
210
208
160
146
129
122
112
111
100
97
91
83
82
82

Journal

53
51
46
30
28
28
21
19
18
17
17
16
16
16
16
15
14
14
14
13

NCATS Publications

7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.


Kiselev E, DeGuire S, Morrell A, Agama K, Dexheimer TS, Pommier Y, Cushman M


J. Med. Chem. , (54), 6106-16, 2011.

Article Pubmed

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Discovery, synthesis, and biological evaluation of novel SMN protein modulators.


Xiao J, Marugan J, Zheng W, Titus S, Southall N, Cherry JJ, Evans M, Androphy EJ, Austin C


J. Med. Chem. , (54), 6215-33, 2011.

Article Pubmed

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Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.


Yuan J, Cheng KC, Johnson RL, Huang R, Pattaradilokrat S, Liu A, Guha R, Fidock DA, Inglese J, Wellems TE, Austin C, Su XZ


Science , (333), 724-9, 2011.

Article Pubmed

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Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.


Kenyon V, Rai Bantukallu G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR


J. Med. Chem. , (54), 5485-97, 2011.

Article Pubmed

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The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.


Morgan HP, McNae IW, Nowicki MW, Zhong W, Michels PA, Auld DS, Fothergill-Gilmore LA, Walkinshaw MD


J. Biol. Chem. , (286), 31232-40, 2011.

Article Pubmed

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Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.


Hall M, Brimacombe K, Varonka MS, Pluchino KM, Monda JK, Li J, Walsh MJ, Boxer MB, Warren TH, Fales HM, Gottesman MM


J. Med. Chem. , (54), 5878-89, 2011.

Article Pubmed

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Adolescent BMI and risk of diabetes versus coronary disease.


Cure Ramirez P, Cure-Cure C


N. Engl. J. Med. , (364), 2558-9; author reply 2559, 2011.

Article Pubmed

Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.


Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M


J. Med. Chem. , (54), 4937-53, 2011.

Article Pubmed

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