Program

21
14
1

Journal Year Published

9
7
7
2
1
7

Author

33
182
174
134
134
125
118
116
114
108
88
86
81
73
56
51
50
43
43
42
34

Category

24
11
5
5
3
1
1

Keyword

10
8
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1

Journal

6
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

NCATS Publications

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.


Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

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Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer.


Vilimas T, Wang A, Patnaik S, Hughes EA, Singleton MD, Knotts Z, Li D, Frankowski K, Schlomer JJ, Guerin TM, Springer S, Drennan C, Dextras C, Wang C, Gilbert D, Southall N, Ferrer-Alegre M, Huang S, Kozlov S, Marugan J, Xu X, Rudloff U


Cancer Chemother. Pharmacol. , 2018.

Article Pubmed

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Discovery and lead identification of quinazoline-based BRD4 inhibitors.


Yang SM, Urban D, Yoshioka M, Strovel JW, Fletcher S, Wang A, Xu X, Shah P, Hu X, Hall M, Jadhav A, Maloney DJ


Bioorg. Med. Chem. Lett. , (28), 3483-3488, 2018.

Article Pubmed

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In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy.


Wiederhold NP, Xu X, Wang A, Najvar LK, Garvey EP, Ottinger E, Alimardanov A, Cradock J, Behnke M, Hoekstra WJ, Brand SR, Schotzinger RJ, Jaramillo R, Olivo M, Kirkpatrick WR, Patterson TF


Antimicrob. Agents Chemother. , 2018.

Article Pubmed

The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.




Clin Transl Sci , 2018.

Article Pubmed

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Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.


Rolt A, Le D, Hu Z, Wang A, Shah P, Singleton M, Hughes E, Dulcey AE, He S, Imamura M, Uchida T, Chayama K, Xu X, Marugan J, Liang TJ


J. Infect. Dis. , 2018.

Article Pubmed

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.


Urban D, Martinez N, Davis MI, Brimacombe K, Cheff D, Lee TD, Henderson M, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall M


Sci Rep , (7), 12758, 2017.

Article Pubmed

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