Program

125
4
3
2
1

Journal Year Published

3
15
11
11
8
18
11
7
5
11
8
13
2
2

Author

125
185
178
145
136
123
118
117
108
99
88
81
77
58
54
50
46
46
42
37

Category

57
49
43
23
15
4
4
1
1
1

Keyword

62
32
27
26
22
21
21
19
14
13
12
10
10
10
9
8
8
7
7
7

Journal

23
15
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1

NCATS Publications

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.


Kearney SE, et al.


ACS Cent Sci , (4), 1727-1741, 2018.

Article Pubmed

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A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).


Sommers JA, Kulikowicz T, Croteau DL, Dexheimer T, Dorjsuren D, Jadhav A, Maloney DJ, Simeonov A, Bohr VA, Brosh RM


PLoS ONE , (14), e0210525, 2019.

Article Pubmed

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.


Manthei KA, Yang SM, Baljinnyam B, Chang L, Glukhova A, Yuan W, Freeman LA, Maloney DJ, Schwendeman A, Remaley AT, Jadhav A, Tesmer JJ


Elife , (7), 2018.

Article Pubmed

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.


Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales S, Lal-Nag M, Rai Bantukallu G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K


Cancer Cell , (34), 939-953.e9, 2018.

Article Pubmed

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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.


Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

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Discovery and lead identification of quinazoline-based BRD4 inhibitors.


Yang SM, Urban DJ, Yoshioka M, Strovel JW, Fletcher S, Wang A, Xu X, Shah P, Hu X, Hall M, Jadhav A, Maloney DJ


Bioorg. Med. Chem. Lett. , (28), 3483-3488, 2018.

Article Pubmed

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Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats.


Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai Bantukallu G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL


Pain , 2018.

Article Pubmed

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KDM5 histone demethylases repress immune response via suppression of STING.


Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai Bantukallu G, Kales S, Henderson M, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall M, Cheng X, Shadel GS, Yan Q


PLoS Biol. , (16), e2006134, 2018.

Article Pubmed

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