Program

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Journal Year Published

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Author

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Category

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Keyword

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Journal

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NCATS Publications

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).


Rai Bantukallu G, Brimacombe K, Mott BT, Urban D, Hu X, Yang SM, Lee TD, Cheff D, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci D, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall M, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (60), 9184-9204, 2017.

Article Pubmed

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Cre dependent DREADD (designer receptors exclusively activated by designer drugs) mice.


Zhu H, Aryal DK, Olsen RH, Urban D, Swearingen A, Forbes S, Roth BL, Hochgeschwender U


Genesis , 2016.

Article Pubmed

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.


Cheng J, Giguere PM, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Huang XP, Zhu H, McCorvy JD, Wetsel WC, Roth BL, Kozikowski AP


J. Med. Chem. , (59), 578-91, 2016.

Article Pubmed

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Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.


Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL


Nature , (527), 477-83, 2015.

Article Pubmed

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A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.


Vardy E, Robinson JE, Li C, Olsen RH, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban D, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL


Neuron , (86), 936-46, 2015.

Article Pubmed

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