Program

10
1

Journal Year Published

1
6
2
1
1

Author

11
212
185
156
149
137
135
129
127
108
107
96
83
79
70
70
63
53
50
46
46

Category

9
4
3

Keyword

1
1
1
1
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Journal

4
2
1
1
1
1
1

NCATS Publications

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.




J Med Chem , (63), 10984-11011, 2020.

Article Pubmed

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Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.


Manthei KA, Yang SM, Baljinnyam B, Chang L, Glukhova A, Yuan W, Freeman LA, Maloney DJ, Schwendeman A, Remaley AT, Jadhav A, Tesmer JJ


Elife , (7), 2018.

Article Pubmed

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Predicting novel therapies and targets: Regulation of Notch3 by the bromodomain protein BRD4.


Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Yang SM, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK


Mol. Cancer Ther. , 2018.

Article Pubmed

Discovery and lead identification of quinazoline-based BRD4 inhibitors.


Yang SM, Urban DJ, Yoshioka M, Strovel JW, Fletcher S, Wang A, Xu X, Shah P, Hu X, Hall M, Jadhav A, Maloney DJ


Bioorg. Med. Chem. Lett. , (28), 3483-3488, 2018.

Article Pubmed

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Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.


Yang SM, Martinez N, Yasgar A, Danchik C, Johansson C, Wang Y, Baljinnyam B, Wang A, Xu X, Shah P, Cheff D, Wang XS, Roth J, Lal-Nag M, Dunford JE, Oppermann U, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , 2018.

Article Pubmed

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DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1.


Cui T, Srivastava AK, Han C, Wu D, Wani N, Liu L, Gao Z, Qu M, Zou N, Zhang X, Yi P, Yu J, Bell EH, Yang SM, Maloney DJ, Zheng Y, Wani AA, Wang QE


Cell Death Dis , (9), 561, 2018.

Article Pubmed

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).


Rai Bantukallu G, Brimacombe K, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff D, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci D, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall M, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (60), 9184-9204, 2017.

Article Pubmed

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