Program

164
16
7
5
3
3
2

Journal Year Published

27
7
23
16
20
13
26
17
13
8
16
8
10
4
2

Author

212
185
156
149
137
135
129
127
108
107
96
83
79
70
70
63
53
50
46
46

Category

79
74
72
29
15
12
6
1
1

Keyword

89
41
35
30
29
24
23
20
15
14
14
13
13
13
10
10
9
9
8
8

Journal

27
18
11
6
6
6
5
5
5
4
4
4
3
3
3
3
3
3
3
3

NCATS Publications

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.


Gorshkov K, Chen C, Bostwick R, Rasmussen L, Tran BN, Cheng Y, Xu M, Pradhan M, Henderson M, Zhu W, Oh E, Susumu K, Wolak M, Shamim K, Huang W, Hu X, Shen M, Klumpp-Thomas C, Itkin Z, Shinn P, Carlos de la Torre J, Simeonov A, Michael S, Hall M, Lo D, Zheng W


ACS Infect Dis , 2020.

Article Pubmed

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Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by Plasmodium falciparum Genotype.


Ansbro MR, Itkin Z, Chen L, Zahoranszky-Kohalmi G, Amaratunga C, Miotto O, Peryea T, Hobbs CV, Suon S, Sá JM, Dondorp AM, van der Pluijm RW, Wellems TE, Simeonov A, Eastman R


ACS Pharmacol Transl Sci , (3), 1144-1157, 2020.

Article Pubmed

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Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.


Abrams RPM, Yasgar A, Teramoto T, Lee MH, Dorjsuren D, Eastman R, Malik N, Zakharov A, Li W, Bachani M, Brimacombe K, Steiner JP, Hall M, Balasubramanian A, Jadhav A, Padmanabhan R, Simeonov A, Nath A


Proc Natl Acad Sci U S A , (117), 31365-31375, 2020.

Article Pubmed

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The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.


Richard AM, Huang R, Waidyanatha S, Shinn P, Collins BJ, Thillainadarajah I, Grulke CM, Williams AJ, Lougee RR, Judson RS, Houck KA, Shobair M, Yang C, Rathman JF, Yasgar A, Fitzpatrick SC, Simeonov A, Thomas RS, Crofton KM, Paules RS, Bucher JR, Austin C, Kavlock RJ, Tice RR


Chem Res Toxicol , 2020.

Article Pubmed

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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.




J Med Chem , (63), 10984-11011, 2020.

Article Pubmed

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