Program

42
5
1
1
1

Journal Year Published

4
7
2
5
3
7
4
6
1
3
3
1

Author

46
212
185
156
149
137
135
129
127
108
107
96
83
79
70
70
63
53
50
46

Category

26
12
11
10
2
1
1

Keyword

22
14
9
8
7
6
6
5
5
4
4
4
3
3
3
3
3
3
3
3

Journal

12
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

NCATS Publications

Identification of a New Heterocyclic Scaffold for Inhibitors of the Polo-Box Domain of Polo-like Kinase 1.


Alverez CN, Park JE, Toti KS, Xia Y, Krausz KW, Rai Bantukallu G, Bang JK, Gonzalez FJ, Jacobson KA, Lee KS


J Med Chem , (63), 14087-14117, 2020.

Article Pubmed

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A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.


Hernandez-Perez M, Kulkarni A, Samala N, Sorrell C, El K, Haider I, Mukhtar Aleem A, Holman TR, Rai Bantukallu G, Tersey SA, Mirmira RG, Anderson RM


FASEB J , (34), 14850-14862, 2020.

Article Pubmed

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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.




J Med Chem , (63), 10984-11011, 2020.

Article Pubmed

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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.


Oshima N, et al.


Cell Rep , (30), 1798-1810.e4, 2020.

Article Pubmed

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.


Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales S, Lal-Nag M, Rai Bantukallu G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K


Cancer Cell , (34), 939-953.e9, 2018.

Article Pubmed

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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.


Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

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Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats.


Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai Bantukallu G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL


Pain , 2018.

Article Pubmed

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KDM5 histone demethylases repress immune response via suppression of STING.


Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai Bantukallu G, Kales S, Henderson M, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall M, Cheng X, Shadel GS, Yan Q


PLoS Biol. , (16), e2006134, 2018.

Article Pubmed

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