Program

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1

Journal Year Published

1
2
1
4
1

Author

9
182
174
134
134
125
118
116
114
108
88
86
81
73
56
51
50
43
43
42
34

Category

8
3
2
2

Keyword

6
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
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Journal

3
1
1
1
1
1
1

NCATS Publications

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.


Stafford WC, Peng X, Olofsson MH, Zhang X, Luci D, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens N, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ


Sci Transl Med , (10), 2018.

Article Pubmed

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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).


Rai Bantukallu G, Brimacombe K, Mott BT, Urban D, Hu X, Yang SM, Lee TD, Cheff D, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci D, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall M, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (60), 9184-9204, 2017.

Article Pubmed

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First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.


Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci D, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M


Arterioscler. Thromb. Vasc. Biol. , (37), 1828-1839, 2017.

Article Pubmed

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.


Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci D, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M


Blood , (124), 2271-9, 2014.

Article Pubmed

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A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.


Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci D, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z


Nat. Chem. Biol. , (10), 298-304, 2014.

Article Pubmed

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Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.


Luci D, Jameson JB, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, Kerns EH, Schultz L, Holinstat M, Nadler JL, Taylor-Fishwick DA, Jadhav A, Simeonov A, Holman TR, Maloney DJ


J. Med. Chem. , (57), 495-506, 2014.

Article Pubmed

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Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion.


Srinivasan P, Yasgar A, Luci D, Beatty WL, Hu X, Andersen J, Narum DL, Moch JK, Sun H, Haynes JD, Maloney DJ, Jadhav A, Simeonov A, Miller LH


Nat Commun , (4), 2261, 2013.

Article Pubmed

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