Program

125
4
3
2
1

Journal Year Published

9
4
15
11
11
8
18
11
7
5
11
8
13
2
2

Author

135
212
185
156
149
137
129
127
108
107
96
83
79
70
70
63
53
50
46
46

Category

57
49
43
23
15
4
4
1
1
1

Keyword

62
32
27
26
22
21
21
19
14
13
12
10
10
10
9
8
8
7
7
7

Journal

24
15
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1

NCATS Publications

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.


Abrams RPM, Yasgar A, Teramoto T, Lee MH, Dorjsuren D, Eastman R, Malik N, Zakharov A, Li W, Bachani M, Brimacombe K, Steiner JP, Hall M, Balasubramanian A, Jadhav A, Padmanabhan R, Simeonov A, Nath A


Proc Natl Acad Sci U S A , (117), 31365-31375, 2020.

Article Pubmed

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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.




J Med Chem , (63), 10984-11011, 2020.

Article Pubmed

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Identification of Small Molecule Enhancers of Immunotherapy for Melanoma.


Dextras C, Dashnyam M, Griner LAM, Sundaresan J, Chim B, Yu Z, Vodnala S, Lee CR, Hu X, Southall N, Marugan J, Jadhav A, Restifo NP, Acquavella N, Ferrer-Alegre M, Singh A


Sci Rep , (10), 5688, 2020.

Article Pubmed

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Endonuclease FEN1 coregulates ERα activity and provides a novel drug interface in tamoxifen resistant breast cancer.


Flach KD, Periyasamy M, Jadhav A, Dorjsuren D, Siefert JC, Hickey TE, Opdam M, Patel H, Canisius S, Wilson DM, Donaldson Collier M, Prekovic S, Nieuwland M, Kluin RJ, Zakharov A, Wesseling J, Wessels LFA, Linn SC, Tilley WD, Simeonov A, Ali S, Zwart W


Cancer Res. , 2020.

Article Pubmed

A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.


Asawa RR, Danchik C, Zahkarov A, Chen Y, Voss T, Jadhav A, Wallace DP, Trott JF, Weiss RH, Simeonov A, Martinez N


Sci Rep , (10), 4203, 2020.

Article Pubmed

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Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells.


Singh A, Dashnyam M, Chim B, Escobar TM, Dulcey AE, Hu X, Wilson K, Koganti PP, Spinner CA, Xu X, Jadhav A, Southall N, Marugan J, Selvaraj V, Lazarevic V, Muljo SA, Ferrer-Alegre M


Sci Rep , (10), 3766, 2020.

Article Pubmed

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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.


Oshima N, et al.


Cell Rep , (30), 1798-1810.e4, 2020.

Article Pubmed

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Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis.


Lyu H, Petukhov PA, Banta PR, Jadhav A, Lea WA, Cheng Q, Arnér ESJ, Simeonov A, Thatcher GRJ, Angelucci F, Williams DL


ACS Infect Dis , (6), 393-405, 2020.

Article Pubmed

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A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.


Bosnakovski D, da Silva MT, Sunny ST, Ener ET, Toso EA, Yuan C, Cui Z, Walters MA, Jadhav A, Kyba M


Sci Adv , (5), eaaw7781, 2019.

Article Pubmed

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