Program

125
5
3
1
1

Journal Year Published

1
15
11
11
8
18
12
8
5
11
8
13
2
2

Author

125
182
174
134
134
118
116
114
108
88
86
81
73
56
51
50
43
43
42
34

Category

58
49
44
23
14
4
4
1
1
1

Keyword

63
33
27
26
22
21
21
20
14
13
12
10
10
10
9
8
8
8
7
7

Journal

23
15
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1

NCATS Publications

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.


Kearney SE, et al.


ACS Cent Sci , (4), 1727-1741, 2018.

Article Pubmed

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A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).


Sommers JA, Kulikowicz T, Croteau DL, Dexheimer T, Dorjsuren D, Jadhav A, Maloney DJ, Simeonov A, Bohr VA, Brosh RM


PLoS ONE , (14), e0210525, 2019.

Article Pubmed

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.


Manthei KA, Yang SM, Baljinnyam B, Chang L, Glukhova A, Yuan W, Freeman LA, Maloney DJ, Schwendeman A, Remaley AT, Jadhav A, Tesmer JJ


Elife , (7), 2018.

Article Pubmed

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.


Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales S, Lal-Nag M, Rai Bantukallu G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K


Cancer Cell , (34), 939-953.e9, 2018.

Article Pubmed

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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.


Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

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Discovery and lead identification of quinazoline-based BRD4 inhibitors.


Yang SM, Urban D, Yoshioka M, Strovel JW, Fletcher S, Wang A, Xu X, Shah P, Hu X, Hall M, Jadhav A, Maloney DJ


Bioorg. Med. Chem. Lett. , (28), 3483-3488, 2018.

Article Pubmed

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Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats.


Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai Bantukallu G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL


Pain , 2018.

Article Pubmed

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KDM5 histone demethylases repress immune response via suppression of STING.


Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai Bantukallu G, Kales S, Henderson M, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall M, Cheng X, Shadel GS, Yan Q


PLoS Biol. , (16), e2006134, 2018.

Article Pubmed

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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.


Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arnér ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F


ACS Chem. Biol. , 2018.

Article Pubmed

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