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NCATS Publications

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.


Egbertson M, et al.


Bioorg. Med. Chem. Lett. , (25), 4812-9, 2015.

Article Pubmed

A sensitive aβ oligomer assay discriminates Alzheimer's and aged control cerebrospinal fluid.


Savage MJ, Kalinina J, Wolfe A, Tugusheva K, Korn R, Cash-Mason T, Maxwell JW, Hatcher NG, Haugabook S, Wu G, Howell BJ, Renger JJ, Shughrue PJ, McCampbell A


J. Neurosci. , (34), 2884-97, 2014.

Article Pubmed

Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.


Stachel SJ, Steele TG, Petrocchi A, Haugabook S, McGaughey G, Katharine Holloway M, Allison T, Munshi S, Zuck P, Colussi D, Tugasheva K, Wolfe A, Graham SL, Vacca JP


Bioorg. Med. Chem. Lett. , (22), 240-4, 2012.

Article Pubmed

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.


Haugabook S, Le V, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, Eckman CB


FASEB J. , (15), 16-18, 2001.

Article Pubmed