Simple, chemoselective hydrogenation with thermodynamic stereocontrol.


Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.


Iwasaki, Kotaro; Wan, Kanny; Oppedisano, Alberto; Crossley, Steven W M; Shenvi, Ryan A;


  • Alkanes/ chemical synthesis
  • Alkanes/ chemistry
  • Alkenes/ chemistry
  • Catalysis
  • Hydrogen/ chemistry
  • Hydrogenation
  • Molecular Structure
  • Stereoisomerism
  • Thermodynamics

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