Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.

Paradigms and Technologies


Shukla, S; Chufan, E E; Singh, Shaurya; Skoumbourdis, A P; Kapoor, K; Boxer, M B; Duveau, Damien; Thomas, Craig; Talele, T T; Ambudkar, S V;


  • Benzamides/ metabolism
  • Binding Sites
  • Fusion Proteins, bcr-abl/ antagonists & inhibitors
  • Humans
  • Imatinib Mesylate
  • P-Glycoprotein/ chemistry
  • P-Glycoprotein/ metabolism
  • Piperazines/ metabolism
  • Protein Kinase Inhibitors/ metabolism
  • Pyrimidines/ metabolism

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