Biology-driven library design for probe discovery.

Methods Development

Abstract

Libraries of diverse small molecules are important to probe and drug discovery. The current trend toward building massive screening collections to support drug development, a special application of chemical biology, can limit their broader potential. Biology-driven construction methods (Wallace et al., 2011) are rapidly emerging to bring chemical libraries back on a viable path.

Authors

Inglese, James; Hasson, Samuel A;

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