Impact of high-throughput screening in biomedical research.

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Abstract

High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. In this article, we aim to dispel these myths and present the case for the use of HTS as part of a proven scientific tool kit, the wider use of which is essential for the discovery of new chemotypes.

Authors

Macarron, Ricardo; Banks, Martyn N; Bojanic, Dejan; Burns, David J; Cirovic, Dragan A; Garyantes, Tina; Green, Darren V S; Hertzberg, Robert P; Janzen, William P; Paslay, Jeff W; Schopfer, Ulrich; Sittampalam, Sitta;

Keywords

  • Animals
  • Biomedical Research
  • Drug Design
  • Drug Evaluation, Preclinical/ standards
  • Drug Evaluation, Preclinical/ statistics & numerical data
  • Humans
  • Small Molecule Libraries

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