Multi-gram scale synthesis of FR180204.

Medicinal Chemistry


A concise synthesis of the ERK inhibitor FR180204 has been developed. The synthesis consists of six operationally simple steps and can be utilized to make multi-gram quantities of FR180204.


Patnaik, Samarjit; Dietz, Harry C; Zheng, Wei; Austin, Christopher; Marugan, Juan;


  • Molecular Structure
  • Pyrazoles/ chemical synthesis
  • Pyrazoles/ chemistry
  • Pyridazines/ chemical synthesis
  • Pyridazines/ chemistry
  • Stereoisomerism

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