Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.

Combination Screening


The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and anti-schistosomal activity.


Rai Bantukallu, Ganesha; Thomas, Craig; Leister, William; Maloney, David J;

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