Program

84
25
4
3
1
1
1

Journal Year Published

7
11
17
12
19
13
8
7
8
2
1

Author

105
201
181
149
139
133
133
125
123
108
95
82
78
63
62
54
50
46
43
43

Category

57
31
27
7
4
2
1
1
1

Keyword

38
21
15
12
12
10
10
8
7
7
7
7
6
6
5
5
5
5
5
5

Journal

9
8
6
6
6
5
3
3
3
2
2
2
2
2
2
2
2
1
1
1

NCATS Publications

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.


He S, Jain P, Lin B, Ferrer-Alegre M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, Marugan J, Liang TJ, Frankowski KJ


ACS Comb Sci , (17), 641-52, 2015.

Article Pubmed

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Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium.


Laurent LC, et al.


J Extracell Vesicles , (4), 26533, 2015.

Article Pubmed

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).


Yang SM, Yasgar A, Miller B, Lal-Nag M, Brimacombe K, Hu X, Sun H, Wang A, Xu X, Nguyen K, Oppermann U, Ferrer-Alegre M, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (58), 5967-78, 2015.

Article Pubmed

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Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?


Sittampalam S, Eglen R, Ferguson S, Maynes JT, Olden K, Schrader L, Shelper T, Ferrer-Alegre M


Assay Drug Dev Technol , (13), 254-61, 2015.

Article Pubmed

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.


He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang A, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer-Alegre M, Zheng W, Chayama K, Marugan J, Liang TJ


Sci Transl Med , (7), 282ra49, 2015.

Article Pubmed

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Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.


Wang W, Gao Q, Yang M, Zhang X, Yu L, Lawas M, Li X, Bryant-Genevier M, Southall N, Marugan J, Ferrer-Alegre M, Xu H


Proc. Natl. Acad. Sci. U.S.A. , (112), E1373-81, 2015.

Article Pubmed

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Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing.


Camargo LM, Zhang XD, Loerch P, Caceres RM, Marine SD, Uva P, Ferrer-Alegre M, de Rinaldis E, Stone DJ, Majercak J, Ray WJ, Yi-An C, Shearman MS, Mizuguchi K


PLoS ONE , (10), e0115369, 2015.

Article Pubmed

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Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.


Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, Zhang Y, Curtis M, Schryver EM, Bettis S, Jadhav A, Boxer MB, Li Z, Ferrer-Alegre M, Lengyel E


Nat Commun , (6), 6220, 2015.

Article Pubmed

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The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.


Cheng X, Zhang X, Gao Q, Ali Samie M, Azar M, Tsang WL, Dong L, Sahoo N, Li X, Zhuo Y, Garrity AG, Wang X, Ferrer-Alegre M, Dowling J, Xu L, Han R, Xu H


Nat. Med. , (20), 1187-92, 2014.

Article Pubmed

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