Program

125
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3
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Journal Year Published

7
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15
11
11
8
18
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2

Author

133
201
181
149
139
133
125
123
108
105
95
82
78
63
62
54
50
46
43
43

Category

57
49
43
23
15
4
4
1
1
1

Keyword

62
32
27
26
22
21
21
19
14
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12
10
10
10
9
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7

Journal

23
15
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NCATS Publications

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.


Van Voorhis WC, et al.


PLoS Pathog. , (12), e1005763, 2016.

Article Pubmed

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Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.


Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JS, Kales S, Mott BT, Rai Bantukallu G, Jansen DJ, Henderson M, Urban DJ, Hall M, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X


Cell Chem Biol , (23), 769-81, 2016.

Article Pubmed

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Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase.


Deschamps JD, Ogunsola AF, Jameson JB, Yasgar A, Flitter BA, Freedman CJ, Melvin JA, Nguyen JV, Maloney DJ, Jadhav A, Simeonov A, Bomberger JM, Holman TR


Biochemistry , (55), 3329-40, 2016.

Article Pubmed

Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors.


Anantpadma M, Kouznetsova J, Wang H, Huang R, Kolokoltsov A, Guha R, Lindstrom AR, Shtanko O, Simeonov A, Maloney DJ, Maury W, LaCount DJ, Jadhav A, Davey RA


Antimicrob. Agents Chemother. , (60), 4471-81, 2016.

Article Pubmed

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Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.


Hu X, Compton JR, Leary DH, Olson MA, Lee MS, Cheung J, Ye W, Ferrer M, Southall N, Jadhav A, Morazzani EM, Glass PJ, Marugan J, Legler PM


Biochemistry , (55), 3007-19, 2016.

Article Pubmed

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A potent and selective inhibitor targeting human and murine 12/15-LOX.


Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, Holman TR


Bioorg. Med. Chem. , (24), 1183-90, 2016.

Article Pubmed

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Microfluidic Mobility Shift Profiling of Lysine Acetyltransferases Enables Screening and Mechanistic Analysis of Cellular Acetylation Inhibitors.


Sorum AW, Shrimp J, Roberts AM, Montgomery DC, Tiwari NK, Lal-Nag M, Simeonov A, Jadhav A, Meier JL


ACS Chem. Biol. , (11), 734-41, 2016.

Article Pubmed

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KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes.


Duan L, Rai Bantukallu G, Roggero C, Zhang QJ, Wei Q, Ma SH, Zhou Y, Santoyo J, Martinez ED, Xiao G, Raj GV, Jadhav A, Simeonov A, Maloney DJ, Rizo J, Hsieh JT, Liu ZP


Chem. Biol. , (22), 1185-96, 2015.

Article Pubmed

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Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).


Yang SM, Yasgar A, Miller B, Lal-Nag M, Brimacombe K, Hu X, Sun H, Wang A, Xu X, Nguyen K, Oppermann U, Ferrer-Alegre M, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (58), 5967-78, 2015.

Article Pubmed

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Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.


Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, Cox K, Austin C, Simeonov A, Sittampalam S, Husain S, Franklin N, Wild DJ, Yang JJ, Sutherland JJ, Thomas C


PLoS ONE , (10), e0130796, 2015.

Article Pubmed

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