Program

164
16
7
5
3
3
2

Journal Year Published

7
23
16
20
13
26
17
13
8
16
8
10
4
2

Author

185
178
145
136
125
123
118
117
108
99
88
81
77
58
54
50
46
46
42
37

Category

79
74
72
29
15
12
6
1
1

Keyword

88
41
35
30
29
24
23
20
15
14
14
13
13
13
10
10
9
9
8
8

Journal

24
18
11
6
5
5
5
4
4
4
4
3
3
3
3
3
3
3
2
2

NCATS Publications

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.


Yang SM, Martinez N, Yasgar A, Danchik C, Johansson C, Wang Y, Baljinnyam B, Wang A, Xu X, Shah P, Cheff D, Wang XS, Roth J, Lal-Nag M, Dunford JE, Oppermann U, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , 2018.

Article Pubmed

Sample image from publication page

Donated chemical probes for open science.


Müller S, et al.


Elife , (7), 2018.

Article Pubmed

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Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.


Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

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The US Federal Tox21 Program: A strategic and operational plan for continued leadership.


Thomas RS, Paules RS, Simeonov A, Fitzpatrick SC, Crofton KM, Casey WM, Mendrick DL


ALTEX , (35), 163-168, 2018.

Article Pubmed

Unexplored therapeutic opportunities in the human genome.


Oprea TI, et al.


Nat Rev Drug Discov , 2018.

Article Pubmed

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Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.


Stafford WC, Peng X, Olofsson MH, Zhang X, Luci D, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ


Sci Transl Med , (10), 2018.

Article Pubmed

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Literature Search and Review.


Simeonov A, Wilson A, Auld D


Assay Drug Dev Technol , 2018.

Article Pubmed

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Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.


Shen M, Asawa R, Zhang Y, Cunningham E, Sun H, Tropsha A, Janzen WP, Muratov EN, Capuzzi SJ, Farag S, Jadhav A, Blatt J, Simeonov A, Martinez N


Oncotarget , (9), 4758-4772, 2018.

Article Pubmed

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