Program

127
5
3
2
1

Journal Year Published

3
15
11
11
8
18
12
8
5
11
8
13
2
2

Author

127
183
175
135
134
119
118
115
108
90
87
81
74
57
52
50
44
43
42
34

Category

59
49
44
23
15
4
4
1
1
1

Keyword

63
33
27
26
22
21
21
20
14
13
12
10
10
10
9
8
8
8
7
7

Journal

23
15
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1

NCATS Publications

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).


Rai Bantukallu G, Brimacombe K, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff D, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci D, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall M, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (60), 9184-9204, 2017.

Article Pubmed

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Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.


Urban DJ, Martinez N, Davis MI, Brimacombe K, Cheff D, Lee TD, Henderson M, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall M


Sci Rep , (7), 12758, 2017.

Article Pubmed

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Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold.


Teske KA, Rai Bantukallu G, Nandhikonda P, Sidhu PS, Feleke B, Simeonov A, Yasgar A, Jadhav A, Maloney DJ, Arnold LA


ACS Comb Sci , (19), 646-656, 2017.

Article Pubmed

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First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.


Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci D, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M


Arterioscler. Thromb. Vasc. Biol. , (37), 1828-1839, 2017.

Article Pubmed

Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands.


Wei J, Zanker D, Di Carluccio AR, Smelkinson MG, Takeda K, Seedhom MO, Dersh D, Gibbs JS, Yang N, Jadhav A, Chen W, Yewdell JW


J. Immunol. , 2017.

Article Pubmed

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A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.


Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT


Proc. Natl. Acad. Sci. U.S.A. , (113), 14366-14371, 2016.

Article Pubmed

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Highly predictive and interpretable models for PAMPA permeability.


Sun H, Nguyen K, Kerns E, Yan Z, Yu KR, Shah P, Jadhav A, Xu X


Bioorg. Med. Chem. , (25), 1266-1276, 2017.

Article Pubmed

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Pharos: Collating protein information to shed light on the druggable genome.


Nguyen T, Mathias S, Bologa C, Brunak S, Fernandez N, Gaulton A, Hersey A, Holmes J, Jensen LJ, Karlsson A, Liu G, Ma'ayan A, Mandava G, Mani S, Mehta S, Overington J, Patel J, Rouillard AD, Schürer S, Sheils T, Simeonov A, Sklar LA, Southall N, Ursu O, Vidovic D, Waller A, Yang J, Jadhav A, Oprea TI, Guha R


Nucleic Acids Res. , (45), D995-D1002, 2017.

Article Pubmed

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