Program

125
4
3
2
1

Journal Year Published

7
4
15
11
11
8
18
11
7
5
11
8
13
2
2

Author

133
201
181
149
139
133
125
123
108
105
95
82
78
63
62
54
50
46
43
43

Category

57
49
43
23
15
4
4
1
1
1

Keyword

62
32
27
26
22
21
21
19
14
13
12
10
10
10
9
8
8
7
7
7

Journal

23
15
5
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1

NCATS Publications

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.


Yang SM, Martinez N, Yasgar A, Danchik C, Johansson C, Wang Y, Baljinnyam B, Wang A, Xu X, Shah P, Cheff D, Wang XS, Roth J, Lal-Nag M, Dunford JE, Oppermann U, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , 2018.

Article Pubmed

Sample image from publication page

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.


Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai Bantukallu G, Mott BT, Jansen DJ, Kales S, Henderson M, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall M, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X


J. Med. Chem. , 2018.

Article Pubmed

Sample image from publication page

Unexplored therapeutic opportunities in the human genome.


Oprea TI, et al.


Nat Rev Drug Discov , 2018.

Article Pubmed

Sample image from publication page

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.


Stafford WC, Peng X, Olofsson MH, Zhang X, Luci D, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ


Sci Transl Med , (10), 2018.

Article Pubmed

Sample image from publication page

Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.


Shen M, Asawa R, Zhang Y, Cunningham E, Sun H, Tropsha A, Janzen WP, Muratov EN, Capuzzi SJ, Farag S, Jadhav A, Blatt J, Simeonov A, Martinez N


Oncotarget , (9), 4758-4772, 2018.

Article Pubmed

Sample image from publication page

Chemical Control of a CRISPR-Cas9 Acetyltransferase.


Shrimp J, Grose C, Widmeyer SRT, Thorpe AL, Jadhav A, Meier JL


ACS Chem. Biol. , (13), 455-460, 2018.

Article Pubmed

Sample image from publication page

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.


Pei F, Li H, Henderson M, Titus SA, Jadhav A, Simeonov A, Cobanoglu MC, Mousavi SH, Shun T, McDermott L, Iyer P, Fioravanti M, Carlisle D, Friedlander RM, Bahar I, Taylor DL, Lezon TR, Stern AM, Schurdak ME


Sci Rep , (7), 17803, 2017.

Article Pubmed

Sample image from publication page

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).


Rai Bantukallu G, Brimacombe K, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff D, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci D, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall M, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (60), 9184-9204, 2017.

Article Pubmed

Sample image from publication page

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.


Urban DJ, Martinez N, Davis MI, Brimacombe K, Cheff D, Lee TD, Henderson M, Titus SA, Pragani R, Rohde JM, Liu L, Fang Y, Karavadhi S, Shah P, Lee OW, Wang A, McIver A, Zheng H, Wang X, Xu X, Jadhav A, Simeonov A, Shen M, Boxer MB, Hall M


Sci Rep , (7), 12758, 2017.

Article Pubmed

Sample image from publication page