Program

27
11
6
3
2

Journal Year Published

2
2
3
2
5
4
6
2
3
2
2

Author

33
183
175
135
134
127
119
118
115
108
90
87
81
74
57
52
50
44
43
42
34

Category

16
10
9
9
1
1
1
1

Keyword

17
9
6
5
5
5
5
5
5
5
5
5
4
3
3
3
3
3
3
3

Journal

6
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

NCATS Publications

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.


Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau D, Jiang J, Michael S, Mierzwa T, Huang W, Walsh MJ, Mott BT, Patel P, Leister W, Maloney DJ, LeClair C, Rai Bantukallu G, Jadhav A, Peyser BD, Austin C, Martin SE, Simeonov A, Ferrer-Alegre M, Staudt LM, Thomas C


Proc. Natl. Acad. Sci. U.S.A. , (111), 2349-54, 2014.

Article Pubmed

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A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.


Jiang J, McCoy JG, Shen M, LeClair C, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G, Choi WS, Volpi E, Fernandez J, Babayeva M, Nedelman MA, Filizola M, Coller BS, Thomas C


Bioorg. Med. Chem. Lett. , (24), 1148-53, 2014.

Article Pubmed

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Chemical signatures and new drug targets for gametocytocidal drug development.


Sun W, Tanaka TQ, Magle CT, Huang W, Southall N, Huang R, Dehdashti SJ, McKew JC, Williamson KC, Zheng W


Sci Rep , (4), 3743, 2014.

Article Pubmed

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A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice.


Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC


Endocrinology , (155), 310-4, 2014.

Article Pubmed

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Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.


Law AJ, Wang Y, Sei Y, O'Donnell P, Piantadosi P, Papaleo F, Straub RE, Huang W, Thomas C, Vakkalanka R, Besterman AD, Lipska BK, Hyde TM, Harrison PJ, Kleinman JE, Weinberger DR


Proc. Natl. Acad. Sci. U.S.A. , (109), 12165-70, 2012.

Article Pubmed

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Non-iminosugar glucocerebrosidase small molecule chaperones.


Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E


Medchemcomm , (3), 56-60, 2012.

Article Pubmed

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Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.


Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas C, Filizola M, Springer TA, Coller BS


Sci Transl Med , (4), 125ra32, 2012.

Article Pubmed

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The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.


Englund EE, Neumann S, Eliseeva E, McCoy JG, Titus S, Zheng W, Southall N, Shin P, Leister W, Thomas C, Inglese J, Austin C, Gershengorn MC, Huang W


Medchemcomm , (2), 1016-1020, 2011.

Article Pubmed

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A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide.


Motabar O, Goldin E, Leister W, Liu K, Southall N, Huang W, Marugan J, Sidransky E, Zheng W


Anal Bioanal Chem , (402), 731-9, 2012.

Article Pubmed

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