Program

22
3
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1

Journal Year Published

1
4
4
3
3
3
1
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2
1

Author

23
201
181
149
139
133
133
125
123
108
105
95
82
78
63
62
54
50
46
43
43

Category

12
8
6
4
1

Keyword

9
5
5
5
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2

Journal

4
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1

NCATS Publications

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.


Pacold ME, et al.


Nat. Chem. Biol. , (12), 452-8, 2016.

Article Pubmed

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Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).


Yang SM, Yasgar A, Miller B, Lal-Nag M, Brimacombe K, Hu X, Sun H, Wang A, Xu X, Nguyen K, Oppermann U, Ferrer-Alegre M, Vasiliou V, Simeonov A, Jadhav A, Maloney DJ


J. Med. Chem. , (58), 5967-78, 2015.

Article Pubmed

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.


Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A, Quick KL, Schlatzer DM, Tang H, Papoian R, Brimacombe K, Shen M, Boxer MB, Jadhav A, Robinson AP, Podojil JR, Miller SD, Miller RH, Tesar PJ


Nature , (522), 216-20, 2015.

Article Pubmed

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Structure activity relationships of human galactokinase inhibitors.


Liu L, Tang M, Walsh MJ, Brimacombe K, Pragani R, Tanega C, Rohde JM, Baker H, Fernandez E, Blackman B, Bougie JM, Leister WH, Auld DS, Shen M, Lai K, Boxer MB


Bioorg. Med. Chem. Lett. , (25), 721-7, 2015.

Article Pubmed

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Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.


Brimacombe K, Walsh MJ, Liu L, Vásquez-Valdivieso MG, Morgan HP, McNae I, Fothergill-Gilmore LA, Michels PA, Auld DS, Simeonov A, Walkinshaw MD, Shen M, Boxer MB


ACS Med Chem Lett , (5), 12-7, 2014.

Article Pubmed

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Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.


Blackford JA, Brimacombe K, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin C, Simons SS


Mol. Endocrinol. , (28), 1194-206, 2014.

Article Pubmed

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Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.


Patnaik S, Marugan J, Liu K, Zheng W, Southall N, Dehdashti SJ, Thorsell A, Heilig M, Bell L, Zook M, Eskay B, Brimacombe K, Austin C


J. Med. Chem. , (56), 9045-56, 2013.

Article Pubmed

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.


Anastasiou D, et al.


Nat. Chem. Biol. , (8), 839-47, 2012.

Article Pubmed

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