Program

769
533
98
85
83
35
26
15
15
11
10
10
9
4
2

Journal Year Published

28
88
169
317
325
375
117
61
47
47
34
17
8
4
4
3
2
2
2
2

Author

165
164
120
117
114
110
105
105
104
77
72
71
61
52
50
41
39
37
33
31

Category

314
306
283
95
85
67
21
18
15
14
3
2

Keyword

1185
579
526
359
331
294
206
180
158
143
121
113
108
105
96
94
90
80
79
76

Journal

46
45
41
28
25
21
18
17
15
14
14
13
13
13
13
13
12
12
11
11

NCATS Publications

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway.


Xia M, Bi K, Huang R, Cho MH, Sakamuru S, Miller SC, Li H, Sun Y, Printen J, Austin C, Inglese J


Mol. Cancer , (8), 117, 2009.

Article Pubmed

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Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.


Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin C, Thomas C, Shoichet BK, Maloney DJ


J. Med. Chem. , (53), 52-60, 2010.

Article Pubmed

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A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.


Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin C, Oppermann U, Simeonov A


Nucleic Acids Res. , (38), e11, 2010.

Article Pubmed

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Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.


Liu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D, Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold JM, Frye SV, Arrowsmith CH, Brown PJ, Simeonov A, Vedadi M, Jin J


J. Med. Chem. , (52), 7950-3, 2009.

Article Pubmed

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Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.


Veith H, Southall N, Huang R, James T, Fayne D, Artemenko N, Shen M, Inglese J, Austin C, Lloyd DG, Auld DS


Nat. Biotechnol. , (27), 1050-5, 2009.

Article Pubmed

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Multi-gram scale synthesis of FR180204.


Patnaik S, Dietz HC, Zheng W, Austin C, Marugan J


J. Org. Chem. , (74), 8870-3, 2009.

Article Pubmed

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Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).


Mott BT, Tanega C, Shen M, Maloney DJ, Shinn P, Leister W, Marugan J, Inglese J, Austin C, Misteli T, Auld DS, Thomas C


Bioorg. Med. Chem. Lett. , (19), 6700-5, 2009.

Article Pubmed

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Dose-response modeling of high-throughput screening data.


Parham F, Austin C, Southall N, Huang R, Tice R, Portier C


J Biomol Screen , (14), 1216-27, 2009.

Article Pubmed

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